研究确定了侵袭性儿童白血病的基因组标记

David Spencer Mangum, MD, 共同主要作者，现为内穆尔儿童健康中心儿科血液学/肿瘤学助理教授, 他还记得十多年前，他作为一名医学生访问HCI的希夫曼实验室时开始从事这项研究. “在我多年的训练中，大发娱乐从未停止过试图理解这是如何发生的.22 deletion could impact children with leukemia. 大发娱乐从许多不同的临床试验中收集数据，以确保这一发现是真实的和可重复的," explains Mangum. “大发娱乐的发现很重要，因为大发娱乐发现复发和死亡的可能性在多个不同的ALL患儿队列中是一致的, including children with Down syndrome."

研究小组希望这一发现能够为儿童白血病的治疗大发娱乐提供新的见解. For example, the frequency of the 22q11.22局灶性缺失表明它可能对白血病的发展很重要, 与更糟糕的结果相结合意味着它可能是未来一个有用的临床预后指标. “患有双缺失白血病的孩子可能需要更多的治疗，或者立即进行骨髓移植，而没有双缺失的孩子可能需要毒性较小的化疗，仍然可以达到良好的效果。. All of this needs to be further explored," says Schiffman.

The study was funded by the National Institutes of Health/National Cancer Institute including CA042014 and CA021765; the Pediatric Cancer Research Program funded by Intermountain Healthcare, Primary Children’s Hospital Foundation, and Department of Pediatrics at University of Utah; the Leukemia & Lymphoma Society Translational Research Program; the American Lebanese Syrian Associated Charities; and Huntsman Cancer Foundation. The study benefited from insights of Professor Sir Mel Greaves, an internationally renowned expert on childhood leukemia. 作者承认参与合作的每个个人和机构的关键作用, including other study co-first authors Clinton Mason, PhD, of University of Utah Health; and Julia Meyer, PhD, of the University of California, San Francisco; and co-senior author Karen Rabin, MD, PhD, of Baylor University. 在线查看该研究的作者和机构的完整名单.